The Glass Ceiling and Persons With Disabilities

Glass Ceiling ReportGlassCeilingBackground2PersonsWithDisabilities.pdf: 8336 downloads, before Oct. 1, 2020

Microbial ecology of Thiobacillus ferrooxidans

FINAL TECHNICAL REPORT TO U.S. DEPARTMENT OF THE INTERIOR Geological Survey Washington. D.C.The contents of this report were developed in part under a grant from the Department of the Interior, U.S. Geological Survey. Grant number 14-08-0001-61313

The iSchool Review SIE

The interdisciplinary nature of iSchools lends itself well to outstanding work but the best pieces, specifically by graduate students in professional degree programs, often go unnoticed. At present, there is no platform to showcase the best professional projects coming out of iSchools. This session will focus on the creation of The iSchool Review, which will highlight and preserve the most exciting work from the iSchool community.Ope

Recent Decisions

Recent Decisions ADMIRALTY--COGSA--BILL OF LADING CARGO DESCRIPTION AND PACKER IDENTITY DETERMINE WHEN A CONTAINER IS A PACKAGE IN COGSA LIABILITY PROCEEDINGS Alan L. Marchisotto ============================ ADMIRALTY--JURISDICTION OVER AVIATION TORT CLAIMS--ADMIRALTY JURISDICTION DOES NOT EXTEND TO AVIATION TORT CLAIMS IN THE ABSENCE OF A SIGNIFICANT RELATIONSHIP BETWEEN THE TORT AND TRADITIONAL MARITIME ACTIVITIES W. H. Schwarzschild III ============================ ALIENS--ALIENS MAY MAINTAIN A CAUSE OF ACTION FOR PRIVATE EMPLOYMENT DISCRIMINATION UNDER 42 U.S.C. § 1981 (1970) Mark M. Greisberger ============================ ANTITRUST--ARTICLE 86 OF THE EEC TREATY APPLIES TO CERTAIN CHANGES IN INTERNAL CORPORATE STRUCTURE Richard P. Granfield =========================== CONSTITUTIONAL LAW--EXECUTIVE POWER--PRESIDENTIAL AUTHORITY TO NEGOTIATE FOREIGN COMMERCIAL AGREEMENTS PURSUANT TO FOREIGN AFFAIRS POWER IS NOT CIRCUMSCRIBED ABSENT EX-PLICIT LEGISLATION Donald B. Cameron, Jr. ========================== JURISDICTION--SECURITIES EXCHANGE ACT OF 1934--SECTION 10(b) APPLIES TO A TRANSACTION IN UNLISTED FOREIGN SECURITIES WHEN SIGNIFICANT FRAUDULENT CONDUCT OCCURS IN THE UNITED STATES Isaac H. Braddock ========================= TARIFFS--TRADE AGREEMENT CONCESSIONS MAY BE SUSPENDED ON A MOST-FAVORED-NATION BASIS WHEN SUCH TREATMENT IS REQUIRED BY INTERNATIONAL AGREEMENTS OF THE UNITED STATES David A. Boillo

Identification of sleep fragmentation-induced gut microbiota alteration and prediction of functional impact in Sprague Dawley rats harboring microbiome derived from multiple human donors

Objectives: Poor quality sleep, including sleep fragmentation (SF), can result in severe health consequences. Gut microbiota symbiotically coexist with the host, making essential contributions to overall well-being. In this study, the effects of both acute (6-day) and chronic (6-week) SF in a humanized rat model were examined to evaluate the impact of SF on this symbiotic relationship. Material and Methods: Human fecal material was transplanted into antibiotic-treated, microbially depleted, Sprague Dawley rats. Animals were subjected to either acute or chronic SF and shifts to gut microbiota were investigated using 16S rRNA sequencing and predictive functional profiles were constructed with PICRUSt. We also investigated SF-induced intestinal microbial adhesion and penetration or increased microbial invasion of selected tissues and organs; as well as changes in crypt/villi architecture. Results: Microbiota profiling indicated that chronic, but not acute, SF significantly decreased the richness of alpha-diversity of distal ileum microbiota, and altered cecum and distal ileum beta-diversity; although both acute and chronic SF significantly changed select populations of microbiota in all three regions. Neither acute nor chronic SF induced changes to microbial adhesion, penetration, or invasion into intestinal tissues or nearby organs. Additionally, we found that chronic SF caused a reduction in villus height in the proximal colon. Discussion: Our study suggests that acute SF alters the gut microbiota in this humanized rat model, while chronic SF produces more pronounced changes to microbiota populations. This study identified potential microbiota targets for the prevention and/or intervention of the adverse effects of S F

Koinonia

Best Practices FeaturesStudents of Concern Committee: Coordinating Care, Connie Horton and Mark Davis Want to Change Student Culture on Your Campus? Do the CORE!, Eric Lowdermilk Spotlight FeaturesYou Only Get 1 Up, Justin Heth and Caleb Farmer The Season, Sharon Virkler Book ReviewsThe Future of Christian Learning: An Evangelical and Catholic Dialogue (by Mark Noll and James Turner), reviewed by Philip D. Byers Restoring Rebecca: A Story of Traumatic Stress, Caregiving and the Unmasking of a Superhero (by Christopher Marchand), reviewed by David M. Johnstone A Review of Culture Making: Recovering our Creative Calling (by Andy Crouch), reviewed by Jeff Rioux Revisiting How Minority Students Experience College: Implications for Planning and Policy (by LKemuel Watson, Melvin Terrell, Doris Wright, Fred Bonner II, Michael Cuyjet, James Gold, Donna Rudy and Dawn Person), reviewed by Joshua Canada Excerpts from Breathe: Finding Freedom to Thrive in Relationships after Childhood Sexual Abuse, Nicole Braddock Bromley ReflectionsMy Journey into Student Affairs, Kim Stave FeaturesThe President\u27s Corner Editor\u27s Deskhttps://pillars.taylor.edu/acsd_koinonia/1079/thumbnail.jp

Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of \u3ci\u3eFOXP1\u3c/i\u3e

Haploinsufficiency of Forkhead box protein P1 (FOXP1), a highly conserved transcription factor, leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. Most of the reported FOXP1 mutations occur on the C-terminus of the protein and cluster around to the forkhead domain. All reported FOXP1 pathogenic variants result in abnormal cellular localization and loss of transcriptional repression activity of the protein product. Here we present three patients with the same FOXP1 mutation, c.1574G\u3eA (p.R525Q), that results in the characteristic loss of transcription repression activity. This mutation, however, represents the first reported FOXP1 mutation that does not result in cytoplasmic or nuclear aggregation of the protein but maintains normal nuclear localization

Satellite observations of fumarole activity at Aluto volcano, Ethiopia : implications for geothermal monitoring and volcanic hazard

J. Biggs, I.M.Watson, W. Hutchison, T.A. Mather and D.M. Pyle are members of the NERC Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics (COMET). This work forms a contribution to the NERC Large Grant RiftVolc (NE/L01372X/1) awarded to J. Biggs. W. Hutchison was funded by NERC studentship NE/J500045/1. I.M. Watson is part of the NASA-ASTER science team and acknowledges NASA and JAXA for the provision of data.Fumaroles are the surface manifestation of hydrothermal circulation and can be influenced by magmatic, hydrothermal, hydrological and tectonic processes. This study investigates the temporal changes in fumarole temperatures and spatial extent on Aluto, a restless volcano in the Main Ethiopian Rift (MER), in order to better understand the controls on fluid circulation and the interaction between the magmatic and hydrothermal systems. Thermal infrared (TIR) satellite images, acquired by the Advanced Spaceborne Thermal Emission and Reflection radiometer (ASTER) over the period of 2004 to 2016, are used to generate time series of the fumarole temperatures and areas. The thermal anomalies identified in the ASTER images coincide with known fumaroles with temperatures > 80 °C and are located on or close to fault structures, which provide a pathway for the rising fluids. Most of the fumaroles, including those along the major zone of hydrothermal upwelling, the Artu Jawe Fault Zone, have pixel-integrated temperature variations of only ~ 2 ± 1.5 °C. The exception are the Bobesa fumaroles located on a hypothesised caldera ring fault which show pixel-integrated temperature changes of up to 9 °C consistent with a delayed response of the hydrothermal system to precipitation. We conclude that fumaroles along major faults are strongly coupled to the magmatic-hydrothermal system and are relatively stable with time, whereas those along shallower structures close to the rift flank are more strongly influenced by seasonal variations in groundwater flow. The use of remote sensing data to monitor the thermal activity of Aluto provides an important contribution towards understanding the behaviour of this actively deforming volcano. This method could be used at other volcanoes around the world for monitoring and geothermal exploration.PostprintPeer reviewe

Molecular basis of FIR-mediated c-myc transcriptional control

The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, FBP recruits its specific repressor (FIR), which acts as an on/off transcriptional switch. Here we describe the molecular basis of FIR recruitment, showing that the tandem RNA recognition motifs of FIR provide a platform for independent FUSE DNA and FBP protein binding and explaining the structural basis of the reversibility of the FBP-FIR interaction. We also show that the physical coupling between FBP and FIR is modulated by a flexible linker positioned sequentially to the recruiting element. Our data explain how the FUSE system precisely regulates c-myc transcription and suggest that a small change in FBP-FIR affinity leads to a substantial effect on c-Myc concentration.MRC Grant-in-aid U11757455

Using a formative simulated patient exercise for curriculum evaluation

BACKGROUND: It is not clear that teaching specific history taking, physical examination and patient teaching techniques to medical students results in durable behavioural changes. We used a quasi-experimental design that approximated a randomized double blinded trial to examine whether a Participatory Decision-Making (PDM) educational module taught in a clerkship improves performance on a Simulated Patient Exercise (SPE) in another clerkship, and how this is influenced by the time between training and assessment. METHODS: Third year medical students in an internal medicine clerkship were assessed on their use of PDM skills in an SPE conducted in the second week of the clerkship. The rotational structure of the third year clerkships formed a pseudo-randomized design where students had 1) completed the family practice clerkship containing a training module on PDM skills approximately four weeks prior to the SPE, 2) completed the family medicine clerkship and the training module approximately 12 weeks prior to the SPE or 3) had not completed the family medicine clerkship and the PDM training module at the time they were assessed via the SPE. RESULTS: Based on limited pilot data there were statistically significant differences between students who received PDM training approximately four weeks prior to the SPE and students who received training approximately 12 weeks prior to the SPE. Students who received training 12 weeks prior to the SPE performed better than those who received training four weeks prior to the SPE. In a second comparison students who received training four weeks prior to the SPE performed better than those who did not receive training but the differences narrowly missed statistical significance (P < 0.05). CONCLUSION: This pilot study demonstrated the feasibility of a methodology for conducting rigorous curricular evaluations using natural experiments based on the structure of clinical rotations. In addition, it provided preliminary data suggesting targeted educational interventions can result in marked improvements in the clinical skills spontaneously exhibited by physician trainees in a setting different from which the skills were taught